Endocrine Abstracts

Background: Among chronic hypoparathyroidism (HypoPT) patients, the baseline prevalence of type 2 diabetes (T2D) appeared to be higher than the general population in previous studies. Since little is known about the potential assocation between HypoPT and T2D, this study evaluated whether HypoPT is associated with increased risk of T2D.Methods: A retrospective cohort study, based on a US commercial claims database (Q1 2007 – Q2 2017), was conducted ...

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

In light of the ever-increasing incidences of obesity and T2DM, development of novel therapeutic or preventative measures to combat these epidemics is of utmost importance. Identification of a causal relationship between an altered maternal metabolic homeostasis and an increased propensity for the unborn child to develop metabolic disorders throughout lifetime has shifted considerable amount of attention towards understanding the underlying cellular and molecular alterations. ...

Objectives: Quality of life (QoL) is severely affected in Graves’ disease (GD) but long-term longitudinal assessment of QoL is lacking. Furthermore, whether QoL is comparable to controls after treatment of GD is unclear. For the first time, we present serial, longitudinal data on thyroid-related QoL during 24 months of follow-up in a cohort of newly diagnosed GD patients. In addition, we compare QoL in GD and controls.Methods: All patients were tre...

Introduction: The presence of brown adipose tissue (BAT) in humans has recently been demonstrated by histology and positron emission tomography (PET). In previous reports, BAT in adults is primarily confined to the upper chest and neck. Here, we report a case of massive BAT infiltration of the visceral adipose tissue in a patient with catecholamine secreting paraganglioma.Methods: The patient was evaluated with [18F]-FDG PET/CT at three occasi...

Objectives: Hypothyroid patients report a diversity of symptoms at disease presentation. We studied how useful symptoms are to predict hypothyroidism, and if this may vary between subgroups of patients.Methods: Patients newly diagnosed with overt autoimmune hypothyroidism (n=140) were prospectively identified in a population by linkage to diagnostic laboratory databases, and we concomitantly enrolled individually sex and age-region matched contr...

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

Background: Physiological elevations of free fatty acids (FFAs) occur in a dynamic bell-shaped fashion lasting some hours, e.g. nocturnally and during exercise. In order to define the metabolic role of physiological elevations in relation to diurnal fluctuations in insulin sensitivity, the present study was designed to identify the metabolic effects of a dynamic 4 hour elevation of FFAs during a glucose clamp.Materials and methods: 8 lean, healthy men we...

Context: Abdominally obese individuals have relative hyposomatotropism, elevated serum markers of inflammation, and increased risk of cardiovascular disease (CVD).Objective: The aim was to study the effect of GH treatment on serum levels of inflammatory markers and vascular adhesion molecules in postmenopausal women with abdominal obesity.Design: Forty postmenopausal women aged 51–63 yrs with abdominal obesity received GH (0.6...

Objectives: The thyroid hormone receptor α (TRα) is crucial for organ development, regulation of growth, heart rate and energy homeostasis. In humans, THRA encodes for the two major TRα isoforms, TRα1 and TRα2. TRα2 is generated by alternative splicing and is unable to bind T3 and thus antagonizes TRα1 signaling. Therefore, the physiological effects of TRα require strictly controlled spatiotemporal expression of TRα isoform...